The following English Premier League matches will be/were played between Saturday, April 14, 2018 and Monday, April 16, 2018.
| Saturday, April 14, 2018 | 12:30 | Southampton | Chelsea |
| Saturday, April 14, 2018 | 15:00 | Burnley | Leicester City |
| Saturday, April 14, 2018 | 15:00 | Crystal Palace | Brighton and Hove Albion |
| Saturday, April 14, 2018 | 15:00 | Huddersfield Town | Watford |
| Saturday, April 14, 2018 | 15:00 | Swansea City | Everton |
| Saturday, April 14, 2018 | 17:30 | Liverpool | Bournemouth |
| Saturday, April 14, 2018 | 19:45 | Tottenham Hotspur | Manchester City |
| Sunday, April 15, 2018 | 13:30 | Newcastle United | Arsenal |
| Sunday, April 15, 2018 | 16:00 | Manchester United | West Bromwich Albion |
| Monday, April 16, 2018 | 20:00 | West Ham United | Stoke City |
